L-371,257


SMILES COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C
InChIKey WDERJSQJYIJOPD-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 507.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OT OXYR Human Vasopressin and oxytocin A pKi 7.7 8.12 8.34 ChEMBL
V1A V1AR Human Vasopressin and oxytocin A pKi 5.5 5.5 5.5 ChEMBL
V2 V2R Human Vasopressin and oxytocin A pKi 4.43 4.43 4.43 ChEMBL
OT OXYR Human Vasopressin and oxytocin A pKi 8.8 8.8 8.8 Guide to Pharmacology
V1A V1AR Rat Vasopressin and oxytocin A pKi 8.43 8.43 8.43 ChEMBL
OT OXYR Rat Vasopressin and oxytocin A pKi 7.72 7.72 7.72 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OT OXYR Human Vasopressin and oxytocin A pEC50 8.34 8.34 8.34 ChEMBL
V1A V1AR Human Vasopressin and oxytocin A pEC50 5.5 5.5 5.5 ChEMBL
V2 V2R Human Vasopressin and oxytocin A pEC50 4.43 4.43 4.43 ChEMBL
OT OXYR Rat Vasopressin and oxytocin A pIC50 6.19 6.19 6.19 ChEMBL