Ro 60-0175


SMILES CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O
InChIKey CEPHEXXZGQBXGT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 4
Molecular weight (Da) 342.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.35 7.34 7.88 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.27 8.7 9.26 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.49 7.96 8.64 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.18 5.18 5.18 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database