ArrestinDb

L-741,626

Agent/drug
Bioactivity

L-741,626

SMILES	OC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1
InChIKey	LLBLNMUONVVVPG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	2
Rotatable bonds	3
Molecular weight (Da)	340.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.20	6.20	6.20	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.42	5.42	5.42	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.22	6.22	6.22	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	7.29	7.29	7.29	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.20	5.20	5.20	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.50	6.50	6.50	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.05	6.11	6.16	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.20	6.20	6.20	Guide to Pharmacology
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.18	5.18	5.18	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	5.97	6.05	6.14	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	7.90	8.20	8.50	Guide to Pharmacology
D₂	DRD2	Human	Dopamine	A	pKi	7.06	7.95	8.62	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	7.95	7.95	7.95	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	6.69	6.98	7.31	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	5.82	6.14	6.66	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	5.82	5.82	5.82	PDSP Ki database
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	6.24	6.24	6.24	ChEMBL

Showing 1 to 17 of 17 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Human	Dopamine	A	pIC50	8.35	8.35	8.35	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	8.35	8.35	8.35	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	7.04	7.04	7.04	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	7.04	7.04	7.04	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.90	4.93	4.95	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	5.50	5.50	5.50	ChEMBL

Showing 1 to 6 of 6 entries

L-741,626

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.