ArrestinDb

lemborexant

Agent/drug
Bioactivity

lemborexant

SMILES	Cc1ncc(OC[C@@]2(c3cccc(F)c3)C[C@H]2C(=O)Nc2ccc(F)cn2)c(C)n1
InChIKey	MUGXRYIUWFITCP-PGRDOPGGSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	410.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb
Structure pdb	6TOT 7XRR

No bioactivity data available.

lemborexant

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 2

Phase III 2

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb
Structure pdb	6TOT 7XRR

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

OX1R	OX₁ receptor	Orexin receptors	Peptide receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	N05C	0.283	3	Yes
OX1R	OX₁ receptor	Orexin receptors	Peptide receptors	Class A	Circadian rhythm sleep-wake disorders, unspecified	7A6Z	N05C	0.074	2	Yes
OX1R	OX₁ receptor	Orexin receptors	Peptide receptors	Class A	Insomnia disorders, unspecified	7A0Z	N05C	0.591	4	Yes
OX2R	OX₂ receptor	Orexin receptors	Peptide receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	N05C	0.283	3	Yes
OX2R	OX₂ receptor	Orexin receptors	Peptide receptors	Class A	Circadian rhythm sleep-wake disorders, unspecified	7A6Z	N05C	0.074	2	Yes
OX2R	OX₂ receptor	Orexin receptors	Peptide receptors	Class A	Insomnia disorders, unspecified	7A0Z	N05C	0.595	4	Yes

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