ArrestinDb

losartan

Agent/drug
Bioactivity

losartan

SMILES	CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
InChIKey	PSIFNNKUMBGKDQ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	2
Rotatable bonds	8
Molecular weight (Da)	422.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.46	5.46	5.46	ChEMBL
AT₁	AGTRB	Rat	Angiotensin	A	pKd	8.21	8.21	8.21	Guide to Pharmacology
AT₁	AGTRA	Rat	Angiotensin	A	pKd	7.40	7.70	8.00	ChEMBL
AT₁	AGTRA	Rat	Angiotensin	A	pKi	7.84	7.85	7.86	ChEMBL
AT₁	AGTRB	Rat	Angiotensin	A	pKi	7.02	7.79	8.44	ChEMBL
AT₁	AGTR1	Rabbit	Angiotensin	A	pKd	6.70	7.94	8.80	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pKd	8.48	8.48	8.48	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pKi	7.77	7.99	8.30	ChEMBL
AT₁	AGTRB	Rat	Angiotensin	A	pKi	7.92	7.92	7.92	PDSP Ki database
AT₁	AGTR1	Rabbit	Angiotensin	A	pKd	8.06	8.06	8.06	Drug Central
AT₁	AGTRB	Rat	Angiotensin	A	pKi	8.07	8.07	8.07	Drug Central
AT₁	AGTRA	Rat	Angiotensin	A	pKi	8.11	8.11	8.11	Drug Central

Showing 1 to 12 of 12 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

AT₁	AGTR1	Human	Angiotensin	A	pIC50	7.40	8.05	8.70	Guide to Pharmacology
AT₁	AGTR1	Bovine	Angiotensin	A	pIC50	6.37	6.70	7.02	ChEMBL
AT₁	AGTR1	Bovine	Angiotensin	A	pEC50	6.46	6.46	6.46	ChEMBL
AT₁	AGTRA	Rat	Angiotensin	A	pIC50	7.72	7.95	8.17	ChEMBL
AT₁	AGTRB	Rat	Angiotensin	A	pIC50	4.44	7.63	8.82	ChEMBL
AT₁	AGTR1	Rabbit	Angiotensin	A	pIC50	7.21	7.49	8.52	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	6.46	7.90	9.48	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	8.02	8.02	8.02	Drug Central
AT₁	AGTR1	Bovine	Angiotensin	A	pIC50	8.15	8.15	8.15	Drug Central
AT₁	AGTR1	Guinea pig	Angiotensin	A	pIC50	7.75	7.75	7.75	ChEMBL
AT₁	AGTR1	Guinea pig	Angiotensin	A	pIC50	8.11	8.11	8.11	Drug Central
AT₂	AGTR2	Rat	Angiotensin	A	pIC50	4.13	4.52	5.13	ChEMBL
AT₂	AGTR2	Human	Angiotensin	A	pIC50	5.00	6.36	7.72	ChEMBL
AT₂	AGTR2	Human	Angiotensin	A	pIC50	8.30	8.30	8.30	Drug Central
AT₂	AGTR2	Rat	Angiotensin	A	pIC50	8.29	8.29	8.29	Drug Central
TP	TA2R	Human	Prostanoid	A	pIC50	4.70	4.70	4.70	ChEMBL

Showing 1 to 16 of 16 entries

losartan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 3

Phase II 11

Phase III 7

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Acute respiratory distress syndrome	CB00	C09C, C09D	0.401	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	COVID-19	RA01	C09C, C09D	0.554	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Chronic kidney disease, stage unspecified	GB61.Z	C09C, C09D	0.595	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Cystic fibrosis, unspecified	CA25.Z	C09C, C09D	0.098	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Diseases of arteries or arterioles, unspecified	BD5Z	C09C, C09D	0.049	1	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Eosinophilic oesophagitis	DA24.1	C09C, C09D	0.094	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Essential hypertension, unspecified	BA00.Z	C09C, C09D	0.708	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Glioblastoma of brain	2A00.00	C09C, C09D	0.349	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Heart failure, unspecified	BD1Z	C09C, C09D	0.611	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified	1C62.Z	C09C, C09D	0.246	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Hypertrophic cardiomyopathy, unspecified	BC43.1Z	C09C, C09D	0.132	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Malignant neoplasms of breast, unspecified	2C6Z	C09C, C09D	0.291	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Marfan syndrome	LD28.01	C09C, C09D	0.398	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Nephritic syndrome	GB40	C09C, C09D	0.366	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Osteoarthritis of knee, unspecified	FA01.Z	C09C, C09D	0.037	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Osteosarcoma of bone and articular cartilage of unspecified sites	2B51.Z	C09C, C09D	0.044	1	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Other specified disorders of muscles	FB32.Y	C09C, C09D	0.075	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Other specified malignant neoplasms of pancreas	2C10.Y	C09C, C09D	0.103	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Pre-eclampsia, unspecified	JA24.Z	C09C, C09D	0.100	1	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Proteinuria, unspecified	MF96.Z	C09C, C09D	0.507	4	Yes

Showing 1 to 20 of 24 entries

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losartan

losartan

Chemical Properties

Database connections

Bioactivities

losartan

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information