losartan
| SMILES | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl |
| InChIKey | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 6 |
| Hydrogen bond donors | 2 |
| Rotatable bonds | 8 |
| Molecular weight (Da) | 422.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| AT1 | AGTRA | Rat | Angiotensin | A | pKi | 7.84 | 7.85 | 7.86 | ChEMBL |
| AT1 | AGTRA | Rat | Angiotensin | A | pKd | 7.4 | 7.7 | 8.0 | ChEMBL |
| AT1 | AGTRB | Rat | Angiotensin | A | pKi | 7.02 | 7.79 | 8.44 | ChEMBL |
| AT1 | AGTR1 | Rabbit | Angiotensin | A | pKd | 6.7 | 7.94 | 8.8 | ChEMBL |
| AT1 | AGTR1 | Human | Angiotensin | A | pKi | 7.77 | 7.99 | 8.3 | ChEMBL |
| AT1 | AGTR1 | Human | Angiotensin | A | pKd | 8.48 | 8.48 | 8.48 | ChEMBL |
| AT1 | AGTR1 | Rabbit | Angiotensin | A | pKd | 8.06 | 8.06 | 8.06 | Drug Central |
| AT1 | AGTRB | Rat | Angiotensin | A | pKd | 8.21 | 8.21 | 8.21 | Guide to Pharmacology |
| AT1 | AGTRB | Rat | Angiotensin | A | pKi | 7.92 | 7.92 | 7.92 | PDSP Ki database |
| AT1 | AGTRB | Rat | Angiotensin | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| AT1 | AGTRA | Rat | Angiotensin | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| AT1 | AGTR1 | Bovine | Angiotensin | A | pIC50 | 6.37 | 6.7 | 7.02 | ChEMBL |
| AT1 | AGTR1 | Bovine | Angiotensin | A | pEC50 | 6.46 | 6.46 | 6.46 | ChEMBL |
| AT1 | AGTRA | Rat | Angiotensin | A | pIC50 | 7.72 | 7.95 | 8.17 | ChEMBL |
| AT1 | AGTRB | Rat | Angiotensin | A | pIC50 | 4.44 | 7.63 | 8.82 | ChEMBL |
| AT2 | AGTR2 | Rat | Angiotensin | A | pIC50 | 4.13 | 4.52 | 5.13 | ChEMBL |
| AT1 | AGTR1 | Rabbit | Angiotensin | A | pIC50 | 7.21 | 7.49 | 8.52 | ChEMBL |
| AT2 | AGTR2 | Human | Angiotensin | A | pIC50 | 5.0 | 6.36 | 7.72 | ChEMBL |
| AT1 | AGTR1 | Human | Angiotensin | A | pIC50 | 6.46 | 7.92 | 9.48 | ChEMBL |
| AT1 | AGTR1 | Human | Angiotensin | A | pIC50 | 7.4 | 8.05 | 8.7 | Guide to Pharmacology |
| AT1 | AGTR1 | Human | Angiotensin | A | pIC50 | 8.02 | 8.02 | 8.02 | Drug Central |
| AT2 | AGTR2 | Human | Angiotensin | A | pIC50 | 8.3 | 8.3 | 8.3 | Drug Central |
| TP | TA2R | Human | Prostanoid | A | pIC50 | 4.7 | 4.7 | 4.7 | ChEMBL |
| AT2 | AGTR2 | Rat | Angiotensin | A | pIC50 | 8.29 | 8.29 | 8.29 | Drug Central |
| AT1 | AGTR1 | Guinea pig | Angiotensin | A | pIC50 | 7.75 | 7.75 | 7.75 | ChEMBL |
| AT1 | AGTR1 | Guinea pig | Angiotensin | A | pIC50 | 8.11 | 8.11 | 8.11 | Drug Central |
| AT1 | AGTR1 | Bovine | Angiotensin | A | pIC50 | 8.15 | 8.15 | 8.15 | Drug Central |