ArrestinDb

loxapine

Agent/drug
Bioactivity

loxapine

SMILES	CN1CCN(C2=Nc3ccccc3Oc3ccc(Cl)cc32)CC1
InChIKey	XJGVXQDUIWGIRW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	0
Rotatable bonds	0
Molecular weight (Da)	327.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₄

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.28	7.28	7.28	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.51	7.51	7.51	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.82	6.82	6.82	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.97	6.97	6.97	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.10	7.10	7.10	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.54	5.58	5.61	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.25	8.25	8.25	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.41	6.41	6.41	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.46	5.46	5.46	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.26	8.26	8.26	Drug Central
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.85	5.85	5.85	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central

Showing 1 to 20 of 86 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pIC50	6.00	6.00	6.00	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pIC50	8.22	8.22	8.22	Drug Central
D₂	DRD2	Human	Dopamine	A	pIC50	7.27	7.27	7.27	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	7.66	7.66	7.66	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	8.12	8.12	8.12	Drug Central
D₄	DRD4	Human	Dopamine	A	pIC50	7.85	7.85	7.85	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	6.00	6.00	6.00	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	8.22	8.22	8.22	Drug Central
H₄	HRH4	Human	Histamine	A	pEC50	6.66	6.66	6.66	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.50	6.03	6.55	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	5.26	5.26	5.26	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	8.28	8.28	8.28	Drug Central

Showing 1 to 12 of 12 entries

loxapine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 10

Phase III 5

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₄

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.609	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Delirium, unspecified or unknown cause	6D70.Z	N05A	0.588	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	N05A	0.479	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Neuropathic pain, unspecified	8E43.0Z	N05A	0.039	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Restlessness	MB24.F	N05A	0.602	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.609	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.620	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.605	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Delirium, unspecified or unknown cause	6D70.Z	N05A	0.549	3	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	N05A	0.472	2	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Neuropathic pain, unspecified	8E43.0Z	N05A	0.037	2	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Restlessness	MB24.F	N05A	0.598	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.589	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.614	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.660	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Delirium, unspecified or unknown cause	6D70.Z	N05A	0.587	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	N05A	0.597	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Neuropathic pain, unspecified	8E43.0Z	N05A	0.037	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Restlessness	MB24.F	N05A	0.602	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.615	4	Yes

Showing 1 to 20 of 35 entries

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loxapine

loxapine

Chemical Properties

Database connections

Bioactivities

loxapine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information