ArrestinDb

LP-44

Agent/drug
Bioactivity

LP-44

SMILES	CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
InChIKey	JNBBJUHCODFLEG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	9
Molecular weight (Da)	451.3

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.28	7.28	7.28	Guide to Pharmacology
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.28	7.28	7.28	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	7.28	7.28	7.28	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.49	6.49	6.49	Guide to Pharmacology
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	9.66	9.66	9.66	Guide to Pharmacology
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	9.66	9.66	9.66	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKd	7.70	7.70	7.70	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	9.66	9.66	9.66	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	8.14	8.14	8.14	Guide to Pharmacology
D₂	DRD2	Human	Dopamine	A	pKi	8.14	8.14	8.14	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	8.14	8.14	8.14	PDSP Ki database

Showing 1 to 11 of 11 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.63	6.63	6.63	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	5.58	5.58	5.58	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pEC50	5.59	5.59	5.59	ChEMBL
GPR65	PSYR	Human	A orphans	A	pIC50	5.40	5.40	5.40	ChEMBL

Showing 1 to 4 of 4 entries

LP-44

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.