LSN2814617


SMILES Fc1ccc(cc1)c1noc(n1)[C@H]1CCn2c(C1)nnc2C(C)(C)C
InChIKey NPRJTKMKUYJGAL-LBPRGKRZSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 341.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 5.87 5.87 5.87 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 7.38 7.38 7.38 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 7.28 7.28 7.28 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 7.28 7.28 7.28 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 7.03 7.03 7.03 Guide to Pharmacology