ArrestinDb

LY2033298

Agent/drug
Bioactivity

LY2033298

SMILES	COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
InChIKey	CTEGQKDJTBWFHW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	3
Molecular weight (Da)	311.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	7TRP
Ligand site mutations	M₄

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKd	4.40	4.40	4.40	Guide to Pharmacology
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	5.50	6.15	6.80	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	6.40	6.41	6.41	ChEMBL

Showing 1 to 3 of 3 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKB	4.90	5.20	5.50	Guide to Pharmacology
M₄	ACM4	Rat	Acetylcholine (muscarinic)	A	pEC50	6.65	6.65	6.65	ChEMBL

Showing 1 to 2 of 2 entries

LY2033298

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	7TRP
Ligand site mutations	M₄

Compound is not listed as a drug.