ArrestinDb

Lysergide

Agent/drug
Bioactivity

Lysergide

SMILES	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1
InChIKey	VAYOSLLFUXYJDT-RDTXWAMCSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	3
Molecular weight (Da)	323.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Structure pdb	5TVN 8IZ4 7SRQ 7SRR 7SRS 7WC6 8ZSP 8JXR 6WGT 8FYT
Ligand site mutations	5-HT_2A 5-HT_2B 5-HT_5A

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.85	6.85	6.85	ChEMBL
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	6.85	6.85	6.85	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	6.13	6.13	6.13	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	6.13	6.13	6.13	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.29	8.29	8.30	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.90	8.94	8.96	ChEMBL
5-HT_1A	A0A4X1UTF5	Pig	5-Hydroxytryptamine	A	pKi	8.59	8.59	8.59	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.39	8.76	9.37	PDSP Ki database
5-HT_1A	F6Q2H9	Bovine	5-Hydroxytryptamine	A	pKi	9.51	9.51	9.51	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.14	8.68	9.19	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.05	8.05	8.05	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.08	8.08	8.08	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	9.00	9.00	9.00	Guide to Pharmacology
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.77	7.40	8.41	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.41	8.41	8.41	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	7.85	7.85	7.85	PDSP Ki database
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pKi	8.00	8.05	8.11	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	7.54	7.93	8.20	PDSP Ki database

Showing 1 to 20 of 82 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	7.80	7.99	8.29	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	8.16	8.16	8.16	Drug Central

Showing 1 to 2 of 2 entries

Lysergide

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Structure pdb	5TVN 8IZ4 7SRQ 7SRR 7SRS 7WC6 8ZSP 8JXR 6WGT 8FYT
Ligand site mutations	5-HT_2A 5-HT_2B 5-HT_5A

Compound is not listed as a drug.