CHEMBL1258999


SMILES Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1
InChIKey GUOJBWOHCJIFQW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 381.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 4.28 4.28 4.28 ChEMBL
D1 DRD1 Pig Dopamine A pKi 4.32 4.32 4.32 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.23 6.23 6.23 ChEMBL
D3 DRD3 Human Dopamine A pKi 4.92 4.92 4.92 ChEMBL
D2 DRD2 Human Dopamine A pKi 4.55 4.56 4.57 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 7.8 7.8 7.8 ChEMBL