ArrestinDb

meclinertant

Agent/drug
Bioactivity

meclinertant

SMILES	COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccnc2cc(Cl)ccc12
InChIKey	DYLJVOXRWLXDIG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	586.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Structure pdb	7UL2 6Z4S 6ZIN
Ligand site mutations	NTS₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₄	DRD4	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₅	DRD5	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
NTS₁	NTR1	Human	Neurotensin	A	pKi	8.40	8.40	8.40	Guide to Pharmacology
NTS₁	NTR1	Rat	Neurotensin	A	pKi	8.00	8.30	8.60	Guide to Pharmacology
NTS₁	NTR1	Rat	Neurotensin	A	pKi	8.59	8.59	8.59	ChEMBL
NTS₁	NTR1	Human	Neurotensin	A	pKd	7.48	7.80	8.08	ChEMBL
NTS₂	NTR2	Human	Neurotensin	A	pKi	6.40	6.40	6.40	Guide to Pharmacology
NTS₂	NTR2	Rat	Neurotensin	A	pKi	7.21	7.21	7.21	ChEMBL
NTS₂	NTR2	Human	Neurotensin	A	pKi	6.38	6.38	6.38	ChEMBL

Showing 1 to 12 of 12 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

FPR3	FPR3	Human	Formylpeptide	A	pIC50	5.30	5.30	5.30	ChEMBL
GPR183	GP183	Human	A orphans	A	pIC50	5.20	5.20	5.20	ChEMBL
NTS₁	NTR1	Human	Neurotensin	A	pIC50	7.50	7.85	8.20	Guide to Pharmacology
NTS₁	NTR1	Rat	Neurotensin	A	pIC50	7.09	7.09	7.09	ChEMBL
NTS₁	NTR1	Human	Neurotensin	A	pEC50	4.51	4.51	4.51	ChEMBL
NTS₁	NTR1	Human	Neurotensin	A	pIC50	7.09	8.04	9.00	ChEMBL
NTS₂	NTR2	Mouse	Neurotensin	A	pIC50	7.10	7.10	7.10	Guide to Pharmacology
NTS₂	NTR2	Rat	Neurotensin	A	pEC50	6.92	6.92	6.92	ChEMBL

Showing 1 to 8 of 8 entries

meclinertant

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Structure pdb	7UL2 6Z4S 6ZIN
Ligand site mutations	NTS₁

Compound is not listed as a drug.