ArrestinDb

melatonin

melatonin

SMILES	COc1ccc2[nH]cc(CCNC(C)=O)c2c1
InChIKey	DRLFMBDRBRZALE-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	2
Rotatable bonds	4
Molecular weight (Da)	232.1

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.20	5.20	5.20	Guide to Pharmacology
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.16	5.24	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.28	8.28	8.28	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_5A	5HT5A	Rat	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
H₃	HRH3	Human	Histamine	A	pKi	9.30	9.30	9.30	ChEMBL
H₃	HRH3	Human	Histamine	A	pKi	8.03	8.03	8.03	Drug Central
MT₁	MTR1A	Human	Melatonin	A	pKd	9.40	9.65	9.90	Guide to Pharmacology
MT₁	MTR1A	Human	Melatonin	A	pKi	9.10	9.40	9.70	Guide to Pharmacology
MT₁	MTR1A	Human	Melatonin	A	pKi	9.06	9.59	10.10	ChEMBL
MT₁	MTR1A	Human	Melatonin	A	pKd	9.82	9.82	9.82	ChEMBL
MT₁	MTR1A	Human	Melatonin	A	pKi	7.40	9.38	11.00	PDSP Ki database
MT₂	MTR1B	Human	Melatonin	A	pKi	9.40	9.60	9.80	Guide to Pharmacology
MT₂	MTR1B	Human	Melatonin	A	pKd	9.00	9.30	9.60	Guide to Pharmacology
MT₂	MTR1B	Human	Melatonin	A	pKi	9.02	9.49	9.92	ChEMBL
MT₂	MTR1B	Human	Melatonin	A	pKd	9.82	9.82	9.82	ChEMBL
MT₂	MTR1B	Human	Melatonin	A	pKi	8.26	9.57	10.52	PDSP Ki database

Showing 1 to 19 of 19 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	7.20	7.20	7.20	ChEMBL
MT₁	MTR1A	Human	Melatonin	A	pIC50	9.00	9.55	9.96	ChEMBL
MT₁	MTR1A	Human	Melatonin	A	pEC50	8.65	9.67	10.66	ChEMBL
MT₁	MTR1A	Human	Melatonin	A	pEC50	8.03	8.03	8.03	Drug Central
MT₂	MTR1B	Human	Melatonin	A	pEC50	7.60	9.36	10.16	ChEMBL
MT₂	MTR1B	Human	Melatonin	A	pIC50	9.28	9.36	9.52	ChEMBL
MT₂	MTR1B	Human	Melatonin	A	pEC50	8.01	8.01	8.01	Drug Central

Showing 1 to 7 of 7 entries

melatonin

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.

This ligand is endogenous.