MK-0893


SMILES COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl
InChIKey DNTVJEMGHBIUMW-IBGZPJMESA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Molecular weight (Da) 587.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 5EE7
Ligand site mutations glucagon

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
glucagon GLR Human Glucagon B1 pKi 7.16 7.16 7.16 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GIP GIPR Human Glucagon B1 pIC50 5.99 5.99 5.99 Guide to Pharmacology
glucagon GLR Human Glucagon B1 pIC50 8.18 8.18 8.18 Guide to Pharmacology
PAC1 PACR Human VIP and PACAP B1 pIC50 5.04 5.04 5.04 Guide to Pharmacology
glucagon E2R517 Dog Glucagon B1 pIC50 6.98 6.98 6.98 ChEMBL
VPAC2 VIPR2 Human VIP and PACAP B1 pIC50 4.89 4.89 4.89 ChEMBL
glucagon GLR Human Glucagon B1 pIC50 7.1 7.7 8.18 ChEMBL
GIP GIPR Human Glucagon B1 pIC50 5.99 5.99 5.99 ChEMBL
VPAC1 VIPR1 Human VIP and PACAP B1 pIC50 4.94 4.94 4.94 ChEMBL
glucagon GLR Rat Glucagon B1 pIC50 6.14 6.14 6.14 ChEMBL
glucagon GLR Mouse Glucagon B1 pIC50 6.91 6.91 6.91 ChEMBL
glucagon A0A1D5QZY8 Rhesus macaque Glucagon B1 pIC50 7.26 7.26 7.26 ChEMBL