MGS0028


SMILES O=C1C[C@@]([C@H]2[C@@H]1[C@]2(F)C(=O)O)(N)C(=O)O
InChIKey KFAGJPNFERWZJA-JKBXLQNXSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 2
Molecular weight (Da) 217.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 8.44 8.44 8.44 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 8.48 8.48 8.48 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 9.2 9.2 9.2 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 9.24 9.24 9.24 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 8.68 8.68 8.68 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pEC50 8.68 8.68 8.68 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pEC50 7.02 8.39 9.24 ChEMBL