ArrestinDb

mianserin

Agent/drug
Bioactivity

mianserin

SMILES	CN1CCN2c3ccccc3Cc3ccccc3C2C1
InChIKey	UEQUQVLFIPOEMF-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	0
Molecular weight (Da)	264.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	5-HT_1A 5-HT_2A 5-HT_2C 5-HT₆

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.60	7.60	7.60	Guide to Pharmacology
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	7.37	7.37	7.37	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.04	7.04	7.04	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKd	6.60	6.60	6.60	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.40	7.40	7.40	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.18	7.18	7.18	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.50	7.50	7.50	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.39	7.39	7.39	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.80	8.06	8.32	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.34	7.98	8.32	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.08	8.08	8.08	Drug Central
α_2A	ADA2A	Bovine	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2A	ADA2A	Bovine	Adrenoceptors	A	pKi	7.77	7.77	7.77	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.62	7.62	7.62	ChEMBL
α_2B	ADA2B	Rat	Adrenoceptors	A	pKi	7.34	7.59	7.85	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central

Showing 1 to 20 of 123 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.65	8.40	10.15	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	6.39	6.39	6.39	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	8.19	8.19	8.19	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.99	7.99	7.99	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.92	6.92	6.92	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	7.08	7.08	7.08	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	7.37	7.53	7.68	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.28	7.28	7.28	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.75	7.16	7.37	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	6.06	6.06	6.06	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	6.40	6.40	6.40	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pIC50	6.42	6.42	6.42	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.68	8.14	8.75	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	8.14	8.14	8.14	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	8.13	8.54	8.94	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	7.07	7.07	7.07	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pIC50	6.94	6.94	6.94	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.26	6.26	6.26	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.45	5.45	5.45	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.15	5.15	5.15	ChEMBL

Showing 1 to 20 of 34 entries

mianserin

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	5-HT_1A 5-HT_2A 5-HT_2C 5-HT₆

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.596	4	Yes
5HT1F	5-HT_1F receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.402	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.607	4	Yes
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.448	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.604	4	Yes
5HT6R	5-HT₆ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.403	4	Yes
5HT7R	5-HT₇ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.404	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.418	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.428	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.418	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.586	4	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.585	4	Yes
ADA2C	α_2C-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.585	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.478	4	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.553	4	Yes

Showing 1 to 15 of 15 entries

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mianserin

mianserin

Chemical Properties

Database connections

Bioactivities

mianserin

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information