ArrestinDb

mirtazapine

Agent/drug
Bioactivity

mirtazapine

SMILES	CN1CCN2c3ncccc3Cc3ccccc3C2C1
InChIKey	RONZAEMNMFQXRA-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	0
Molecular weight (Da)	265.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.43	6.43	6.43	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.80	6.95	7.10	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.70	7.70	7.70	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.70	7.70	7.70	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.10	6.40	6.70	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.00	7.35	7.70	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.75	7.75	7.75	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.74	7.74	7.74	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	5.30	5.30	5.30	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.75	7.75	7.75	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.74	7.74	7.74	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	8.28	8.28	8.28	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.16	7.16	7.16	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.16	7.62	8.09	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.16	7.16	7.16	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.15	8.15	8.15	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.41	7.41	7.41	Guide to Pharmacology
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	8.26	8.26	8.26	ChEMBL

Showing 1 to 20 of 45 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	5.50	5.50	5.50	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	8.26	8.26	8.26	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	7.10	7.10	7.10	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	7.07	7.07	7.07	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.65	6.65	6.65	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	8.18	8.18	8.18	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.70	6.70	6.70	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.70	6.70	6.70	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.50	4.50	4.50	ChEMBL

Showing 1 to 9 of 9 entries

mirtazapine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 10

Phase II 41

Phase III 25

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	N06A	0.268	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anorexia	MG43.7	N06A	0.293	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anorexia Nervosa, unspecified	6B80.Z	N06A	0.508	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anxiety	MB24.3	N06A	0.575	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Cachexia, unspecified	MG20.Z	N06A	0.074	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Chronic widespread pain	MG30.01	N06A	0.561	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	N06A	0.460	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.607	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Disorders due to substance use, unspecified	6C4Z	N06A	0.508	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Excessive weight loss	MG43.5	N06A	0.083	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Insomnia disorders, unspecified	7A0Z	N06A	0.564	1	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	N06A	0.543	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Obstructive sleep apnoea	7A41	N06A	0.050	1	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Opioid dependence, unspecified	6C43.2Z	N06A	0.142	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N06A	0.632	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Stimulant dependence including amphetamines, methamphetamine or methcathinone, unspecified	6C46.2Z	N06A	0.546	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Unknown or unspecified psychoactive substance dependence, substance and state of remission unspecified	6C4G.2Z	N06A	0.480	2	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	N06A	0.389	2	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anorexia	MG43.7	N06A	0.291	3	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anorexia Nervosa, unspecified	6B80.Z	N06A	0.480	2	Yes

Showing 1 to 20 of 85 entries

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mirtazapine

mirtazapine

Chemical Properties

Database connections

Bioactivities

mirtazapine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information