CHEMBL1277104


SMILES CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1
InChIKey OQGLQARWXJXSKS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 406.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.24 6.24 6.24 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.8 8.8 8.8 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.22 6.22 6.22 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.48 6.48 6.48 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 8.1 8.1 8.1 ChEMBL