ML375
SMILES | Clc1ccc(cc1)[C@]12N(CCN1C(=O)c1c2cccc1)C(=O)c1ccc(c(c1)F)F |
InChIKey | GXBAKXRLQAPKEE-QHCPKHFHSA-N |
Chemical properties
Hydrogen bond acceptors | 2 |
Hydrogen bond donors | 0 |
Rotatable bonds | 2 |
Molecular weight (Da) | 424.1 |
Drug properties
Molecular type | Small molecule |
Physiological/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.96 | 6.25 | 6.52 | ChEMBL |
M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKB | 6.2 | 6.4 | 6.6 | Guide to Pharmacology |
M5 | ACM5 | Rat | Acetylcholine (muscarinic) | A | pIC50 | 6.1 | 6.1 | 6.1 | ChEMBL |