adenosine


SMILES OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N
InChIKey OIRDTQYFTABQOQ-KQYNXXCUSA-N

Chemical properties

Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 2
Molecular weight (Da) 267.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Endogenous
Approved drug Yes

Database connections

Structure pdb 2YDO 6D9H 8HDP 7LD4 7LD3
Ligand site mutations A1 A2A A2B A3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
A1 AA1R Human Adenosine A pKi 7.0 7.0 7.0 Guide to Pharmacology
A1 AA1R Rat Adenosine A pKi 7.14 7.14 7.14 Guide to Pharmacology
A3 AA3R Human Adenosine A pKi 6.54 6.54 6.54 Guide to Pharmacology
A2B AA2BR Rat Adenosine A pKi 5.29 5.29 5.29 Guide to Pharmacology
A3 AA3R Rat Adenosine A pKi 5.19 5.19 5.19 Guide to Pharmacology
A2A AA2AR Rat Adenosine A pKi 6.82 6.82 6.82 Guide to Pharmacology
A3 AA3R Rat Adenosine A pKi 7.0 7.0 7.0 ChEMBL
A1 AA1R Human Adenosine A pKi 6.09 6.09 6.09 ChEMBL
A1 AA1R Human Adenosine A pKd 6.53 6.53 6.53 ChEMBL
A3 AA3R Human Adenosine A pKi 8.18 8.18 8.18 Drug Central
A3 AA3R Rat Adenosine A pKi 8.15 8.15 8.15 Drug Central
A2A AA2AR Human Adenosine A pKi 6.51 6.51 6.51 Guide to Pharmacology
A2A AA2AR Human Adenosine A pKi 6.16 6.89 7.7 ChEMBL
A2A AA2AR Human Adenosine A pKd 7.76 7.76 7.76 ChEMBL
A2B AA2BR Human Adenosine A pKi 4.82 4.82 4.82 Guide to Pharmacology
A3 AA3R Human Adenosine A pKd 6.13 6.13 6.13 ChEMBL
A3 AA3R Human Adenosine A pKi 6.54 6.54 6.54 ChEMBL
A1 AA1R Rat Adenosine A pKi 4.54 7.24 8.29 ChEMBL
A1 AA1R Rat Adenosine A pKd 5.71 5.71 5.71 ChEMBL
A1 AA1R Rat Adenosine A pKi 8.08 8.08 8.08 Drug Central
A2A AA2AR Rat Adenosine A pKi 7.52 7.52 7.52 ChEMBL
A2A AA2AR Rat Adenosine A pKi 8.12 8.12 8.12 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
A1 AA1R Human Adenosine A pEC50 5.6 6.51 7.41 ChEMBL
A1 AA1R Human Adenosine A pIC50 8.63 8.63 8.63 ChEMBL
A1 AA1R Human Adenosine A pEC50 8.19 8.19 8.19 Drug Central
A2A AA2AR Human Adenosine A pEC50 8.21 8.21 8.21 Drug Central
A2B AA2BR Human Adenosine A pEC50 8.34 8.34 8.34 Drug Central
A2A AA2AR Human Adenosine A pEC50 4.4 5.98 7.6 ChEMBL
A2B AA2BR Human Adenosine A pEC50 4.29 4.95 7.28 ChEMBL
A3 AA3R Human Adenosine A pEC50 5.98 6.67 7.87 ChEMBL
A3 AA3R Human Adenosine A pIC50 8.94 8.94 8.94 ChEMBL
A1 AA1R Guinea pig Adenosine A pEC50 5.47 5.47 5.47 ChEMBL