afamelanotide


SMILES None
InChIKey UAHFGYDRQSXQEB-LEBBXHLNSA-N
Sequence SYSXEHFRWGKPV

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7F54 7PIV
Ligand site mutations MC4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC3 MC3R Human Melanocortin A pKi 8.9 8.9 8.9 Guide to Pharmacology
MC4 MC4R Human Melanocortin A pKi 8.5 8.65 8.8 Guide to Pharmacology
MC4 MC4R Human Melanocortin A pKi 7.72 9.0 9.52 ChEMBL
MC1 MSHR Human Melanocortin A pKi 8.74 9.46 10.34 ChEMBL
MC3 MC3R Human Melanocortin A pKi 9.11 9.14 9.17 ChEMBL
MC5 MC5R Human Melanocortin A pKi 8.0 8.66 9.32 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC1 MSHR Human Melanocortin A pIC50 10.0 10.0 10.0 Guide to Pharmacology
MC5 MC5R Human Melanocortin A pIC50 9.0 9.0 9.0 Guide to Pharmacology
MC1 MSHR Mouse Melanocortin A pEC50 7.92 10.42 11.0 ChEMBL
MC1 MSHR Mouse Melanocortin A pIC50 9.51 9.52 9.54 ChEMBL
MC4 MC4R Human Melanocortin A pIC50 7.85 8.96 9.82 ChEMBL
MC4 MC4R Human Melanocortin A pEC50 8.05 9.27 10.77 ChEMBL
MC1 MSHR Human Melanocortin A pEC50 9.3 9.95 10.64 ChEMBL
MC1 MSHR Human Melanocortin A pIC50 9.29 9.29 9.29 ChEMBL
MC3 MC3R Human Melanocortin A pEC50 8.17 9.15 9.89 ChEMBL
MC3 MC3R Human Melanocortin A pIC50 8.42 8.63 8.93 ChEMBL
MC5 MC5R Human Melanocortin A pIC50 8.66 8.9 9.07 ChEMBL
MC5 MC5R Human Melanocortin A pEC50 8.96 9.21 9.64 ChEMBL
MC3 MC3R Mouse Melanocortin A pEC50 7.12 9.76 10.2 ChEMBL
MC3 MC3R Mouse Melanocortin A pIC50 8.09 8.25 8.38 ChEMBL
MC3 MC3R Rat Melanocortin A pEC50 10.0 10.0 10.0 ChEMBL
MC4 MC4R Mouse Melanocortin A pEC50 6.92 9.48 10.01 ChEMBL
MC4 MC4R Mouse Melanocortin A pIC50 8.38 8.73 8.96 ChEMBL
MC5 MC5R Mouse Melanocortin A pEC50 6.77 9.71 10.52 ChEMBL
MC5 MC5R Mouse Melanocortin A pIC50 6.85 6.85 6.85 ChEMBL