ArrestinDb

PBF-509

Agent/drug
Bioactivity

PBF-509

SMILES	Nc1nc(-n2cccn2)nc(-n2cccn2)c1Br
InChIKey	ATFXVNUWQOXRRU-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	1
Rotatable bonds	2
Molecular weight (Da)	305.0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

A₁	AA1R	Human	Adenosine	A	pKi	5.60	5.60	5.60	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pKi	7.76	7.76	7.76	Guide to Pharmacology
A_2A	AA2AR	Human	Adenosine	A	pKi	7.30	7.69	7.92	ChEMBL
A_2B	AA2BR	Human	Adenosine	A	pKi	6.00	6.00	6.00	ChEMBL
A₃	AA3R	Human	Adenosine	A	pKi	5.30	5.30	5.30	ChEMBL

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

A_2A	AA2AR	Human	Adenosine	A	pIC50	7.60	7.92	8.25	ChEMBL
A_2B	AA2BR	Human	Adenosine	A	pIC50	6.17	6.17	6.17	ChEMBL

Showing 1 to 2 of 2 entries

PBF-509

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 1

Phase II 1

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Other specified malignant neoplasms of bronchus or lung	2C25.Y		0.120	2	No
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Parkinson disease, unspecified	8A00.0Z		0.573	1	No

Showing 1 to 2 of 2 entries