ArrestinDb

pentoxifylline

Agent/drug
Bioactivity

pentoxifylline

SMILES	CC(=O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O
InChIKey	BYPFEZZEUUWMEJ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	0
Rotatable bonds	5
Molecular weight (Da)	278.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

A₁	AA1R	Rat	Adenosine	A	pKi	5.00	5.00	5.00	PDSP Ki database
A₁	AA1R	Bovine	Adenosine	A	pKi	5.00	5.00	5.00	PDSP Ki database
A_2B	AA2BR	Human	Adenosine	A	pKi	5.29	5.29	5.29	Guide to Pharmacology
A_2B	AA2BR	Human	Adenosine	A	pKi	5.29	5.29	5.29	ChEMBL
A_2B	AA2BR	Human	Adenosine	A	pKi	8.28	8.28	8.28	Drug Central

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	7.15	7.15	7.15	ChEMBL
RXFP1	RXFP1	Human	Relaxin family peptide	A	Potency	4.75	4.78	4.80	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.50	4.70	4.80	ChEMBL

Showing 1 to 3 of 3 entries

pentoxifylline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 24

Phase II 38

Phase III 20

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Acute ischaemic heart disease, unspecified	BA4Z	R03D, C04A	0.389	2	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Acute kidney failure, stage unspecified	GB60.Z	R03D, C04A	0.516	2	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Acute pancreatitis, unspecified	DC31.Z	R03D, C04A	0.018	1	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Alcoholic hepatitis, unspecified	DB94.1Z	R03D, C04A	0.483	3	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Anaemias or other erythrocyte disorders, unspecified	3A9Z	R03D, C04A	0.042	1	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Behçet disease	4A62	R03D, C04A	0.092	2	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Biliary atresia	LB20.21	R03D, C04A	0.074	2	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	R03D, C04A	0.021	1	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Brachial plexus disorders, unspecified	8B91.Z	R03D, C04A	0.259	3	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	COVID-19	RA01	R03D, C04A	0.094	1	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Chronic kidney disease, stage unspecified	GB61.Z	R03D, C04A	0.507	3	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Crohn disease, unspecified site	DD70.Z	R03D, C04A	0.381	1	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Cutaneous leishmaniasis	1F54.1	R03D, C04A	0.092	2	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Depressive disorders, unspecified	6A7Z	R03D, C04A	0.048	1	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Diseases of coronary artery, unspecified	BA8Z	R03D, C04A	0.512	2	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	R03D, C04A	0.527	4	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Duchenne muscular dystrophy	8C70.1	R03D, C04A	0.046	1	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Endometriosis of unspecified site	GA10.Z	R03D, C04A	0.259	3	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Hepatic cirrhosis	DB93.1	R03D, C04A	0.259	3	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified	1C62.Z	R03D, C04A	0.383	1	Yes

Showing 1 to 20 of 78 entries

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pentoxifylline

pentoxifylline

Chemical Properties

Database connections

Bioactivities

pentoxifylline

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information