PGE2
SMILES | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O |
InChIKey | XEYBRNLFEZDVAW-ARSRFYASSA-N |
Chemical properties
Hydrogen bond acceptors | 4 |
Hydrogen bond donors | 3 |
Rotatable bonds | 12 |
Molecular weight (Da) | 352.2 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Endogenous |
Approved drug | Yes |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
DP1 | PD2R | Human | Prostanoid | A | pKi | 6.5 | 6.75 | 7.0 | Guide to Pharmacology |
DP2 | PD2R2 | Human | Prostanoid | A | pKi | 5.3 | 5.3 | 5.3 | Guide to Pharmacology |
EP1 | PE2R1 | Mouse | Prostanoid | A | pKi | 7.7 | 7.7 | 7.7 | Guide to Pharmacology |
DP2 | PD2R2 | Mouse | Prostanoid | A | pKi | 5.5 | 5.5 | 5.5 | Guide to Pharmacology |
EP2 | PE2R2 | Human | Prostanoid | A | pKi | 7.5 | 7.9 | 8.3 | Guide to Pharmacology |
EP2 | PE2R2 | Human | Prostanoid | A | pKd | 7.7 | 7.8 | 7.9 | Guide to Pharmacology |
EP3 | PE2R3 | Human | Prostanoid | A | pKd | 8.2 | 8.73 | 9.5 | Guide to Pharmacology |
EP3 | PE2R3 | Human | Prostanoid | A | pKi | 9.48 | 9.48 | 9.48 | Guide to Pharmacology |
EP4 | PE2R4 | Human | Prostanoid | A | pKi | 8.1 | 8.6 | 9.1 | Guide to Pharmacology |
EP4 | PE2R4 | Human | Prostanoid | A | pKd | 7.62 | 8.57 | 9.52 | Guide to Pharmacology |
FP | PF2R | Human | Prostanoid | A | pKi | 6.4 | 6.65 | 6.9 | Guide to Pharmacology |
TP | TA2R | Human | Prostanoid | A | pKi | 4.5 | 4.5 | 4.5 | Guide to Pharmacology |
EP3 | PE2R3 | Rat | Prostanoid | A | pKi | 9.0 | 9.0 | 9.0 | Guide to Pharmacology |
EP3 | PE2R3 | Rat | Prostanoid | A | pKd | 7.82 | 8.72 | 9.1 | Guide to Pharmacology |
EP3 | PE2R3 | Mouse | Prostanoid | A | pKi | 9.07 | 9.07 | 9.07 | Guide to Pharmacology |
EP3 | PE2R3 | Mouse | Prostanoid | A | pKd | 8.85 | 8.85 | 8.85 | Guide to Pharmacology |
EP1 | PE2R1 | Rat | Prostanoid | A | pKi | 7.7 | 7.7 | 7.7 | Guide to Pharmacology |
EP1 | PE2R1 | Rat | Prostanoid | A | pKd | 7.3 | 7.45 | 7.6 | Guide to Pharmacology |
FP | PF2R | Mouse | Prostanoid | A | pKi | 7.0 | 7.0 | 7.0 | Guide to Pharmacology |
EP2 | PE2R2 | Rat | Prostanoid | A | pKi | 8.2 | 8.2 | 8.2 | Guide to Pharmacology |
EP2 | PE2R2 | Rat | Prostanoid | A | pKd | 7.8 | 8.05 | 8.3 | Guide to Pharmacology |
EP4 | PE2R4 | Rat | Prostanoid | A | pKi | 9.0 | 9.0 | 9.0 | Guide to Pharmacology |
EP4 | PE2R4 | Rat | Prostanoid | A | pKd | 9.0 | 9.0 | 9.0 | Guide to Pharmacology |
EP4 | PE2R4 | Mouse | Prostanoid | A | pKd | 8.6 | 8.6 | 8.6 | Guide to Pharmacology |
EP4 | PE2R4 | Mouse | Prostanoid | A | pKi | 8.52 | 8.61 | 8.7 | Guide to Pharmacology |
EP2 | PE2R2 | Mouse | Prostanoid | A | pKi | 7.4 | 7.65 | 7.9 | Guide to Pharmacology |
EP2 | PE2R2 | Mouse | Prostanoid | A | pKd | 7.7 | 7.7 | 7.7 | Guide to Pharmacology |
EP1 | PE2R1 | Human | Prostanoid | A | pKd | 7.6 | 7.75 | 7.9 | Guide to Pharmacology |
EP1 | PE2R1 | Human | Prostanoid | A | pKi | 7.3 | 7.65 | 8.0 | Guide to Pharmacology |
EP2 | PE2R2 | Mouse | Prostanoid | A | pKi | 7.66 | 7.66 | 7.66 | ChEMBL |
EP1 | PE2R1 | Human | Prostanoid | A | pKi | 7.75 | 7.94 | 8.04 | ChEMBL |
EP2 | PE2R2 | Human | Prostanoid | A | pKi | 7.42 | 8.35 | 8.99 | ChEMBL |
EP3 | PE2R3 | Human | Prostanoid | A | pKi | 8.3 | 8.98 | 9.48 | ChEMBL |
EP4 | PE2R4 | Human | Prostanoid | A | pKi | 8.51 | 9.2 | 9.96 | ChEMBL |
EP4 | PE2R4 | Mouse | Prostanoid | A | pKi | 8.72 | 8.72 | 8.72 | PDSP Ki database |
EP1 | PE2R1 | Mouse | Prostanoid | A | pKi | 7.7 | 7.7 | 7.7 | PDSP Ki database |
EP3 | PE2R3 | Mouse | Prostanoid | A | pKi | 9.07 | 9.07 | 9.07 | PDSP Ki database |
EP2 | PE2R2 | Mouse | Prostanoid | A | pKi | 7.92 | 7.92 | 7.92 | PDSP Ki database |
FP | PF2R | Bovine | Prostanoid | A | pKi | 5.47 | 5.47 | 5.47 | PDSP Ki database |
EP3 | PE2R3 | Bovine | Prostanoid | A | pKi | 8.4 | 8.46 | 8.52 | PDSP Ki database |
EP1 | PE2R1 | Human | Prostanoid | A | pKi | 8.04 | 8.04 | 8.04 | PDSP Ki database |
EP4 | PE2R4 | Human | Prostanoid | A | pKi | 8.31 | 8.71 | 9.1 | PDSP Ki database |
DP1 | PD2R | Human | Prostanoid | A | pKi | 6.51 | 6.51 | 6.51 | PDSP Ki database |
EP3 | PE2R3 | Human | Prostanoid | A | pKi | 9.48 | 9.48 | 9.48 | PDSP Ki database |
FP | PF2R | Human | Prostanoid | A | pKi | 6.92 | 6.92 | 6.92 | PDSP Ki database |
IP | PI2R | Human | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
TP | TA2R | Mouse | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
IP | PI2R | Mouse | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
DP2 | PD2R2 | Mouse | Prostanoid | A | pKi | 8.26 | 8.26 | 8.26 | Drug Central |
DP1 | PD2R | Human | Prostanoid | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
DP2 | PD2R2 | Human | Prostanoid | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
EP1 | PE2R1 | Human | Prostanoid | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
EP2 | PE2R2 | Human | Prostanoid | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
EP3 | PE2R3 | Human | Prostanoid | A | pKi | 8.02 | 8.02 | 8.02 | Drug Central |
EP4 | PE2R4 | Human | Prostanoid | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
FP | PF2R | Human | Prostanoid | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
TP | TA2R | Human | Prostanoid | A | pKi | 8.35 | 8.35 | 8.35 | Drug Central |
EP3 | PE2R3 | Mouse | Prostanoid | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
FP | PF2R | Mouse | Prostanoid | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
EP4 | PE2R4 | Mouse | Prostanoid | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
EP2 | PE2R2 | Mouse | Prostanoid | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
EP1 | PE2R1 | Rat | Prostanoid | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
EP1 | PE2R1 | Mouse | Prostanoid | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
EP1 | PE2R1 | Mouse | Prostanoid | A | pKi | 8.22 | 8.22 | 8.22 | ChEMBL |
EP3 | PE2R3 | Mouse | Prostanoid | A | pKi | 8.3 | 8.3 | 8.3 | ChEMBL |
FP | PF2R | Mouse | Prostanoid | A | pKi | 7.0 | 7.0 | 7.0 | PDSP Ki database |
EP4 | PE2R4 | Mouse | Prostanoid | A | pKi | 8.51 | 8.51 | 8.51 | ChEMBL |
DP1 | PD2R | Rat | Prostanoid | A | pKi | 5.53 | 5.53 | 5.53 | PDSP Ki database |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
EP4 | PE2R4 | Human | Prostanoid | A | pEC50 | 6.05 | 6.05 | 6.05 | Guide to Pharmacology |
EP3 | PE2R3 | Rat | Prostanoid | A | pEC50 | 9.39 | 9.39 | 9.39 | Guide to Pharmacology |
EP2 | PE2R2 | Rat | Prostanoid | A | pEC50 | 7.72 | 8.71 | 9.7 | ChEMBL |
EP2 | PE2R2 | Rat | Prostanoid | A | pIC50 | 8.28 | 8.28 | 8.28 | ChEMBL |
EP4 | PE2R4 | Rat | Prostanoid | A | pEC50 | 8.46 | 8.8 | 9.15 | ChEMBL |
EP4 | PE2R4 | Rat | Prostanoid | A | pIC50 | 8.68 | 8.68 | 8.68 | ChEMBL |
IP | PI2R | Human | Prostanoid | A | pIC50 | 6.58 | 6.58 | 6.58 | ChEMBL |
IP | PI2R | Human | Prostanoid | A | pEC50 | 6.46 | 6.46 | 6.46 | ChEMBL |
EP1 | PE2R1 | Human | Prostanoid | A | pEC50 | 8.43 | 8.43 | 8.43 | ChEMBL |
EP1 | PE2R1 | Human | Prostanoid | A | pIC50 | 8.96 | 8.96 | 8.96 | ChEMBL |
EP2 | PE2R2 | Human | Prostanoid | A | pIC50 | 7.42 | 8.36 | 8.66 | ChEMBL |
EP2 | PE2R2 | Human | Prostanoid | A | pEC50 | 6.46 | 7.67 | 8.72 | ChEMBL |
EP3 | PE2R3 | Human | Prostanoid | A | pEC50 | 8.6 | 8.6 | 8.6 | ChEMBL |
EP3 | PE2R3 | Human | Prostanoid | A | pIC50 | 9.03 | 9.03 | 9.03 | ChEMBL |
EP4 | PE2R4 | Human | Prostanoid | A | pEC50 | 8.12 | 9.02 | 10.7 | ChEMBL |
EP4 | PE2R4 | Human | Prostanoid | A | pIC50 | 8.0 | 8.78 | 9.35 | ChEMBL |
EP3 | PE2R3 | Rat | Prostanoid | A | pEC50 | 8.03 | 8.03 | 8.03 | Drug Central |
IP | PI2R | Human | Prostanoid | A | pIC50 | 8.18 | 8.18 | 8.18 | Drug Central |
EP2 | PE2R2 | Rat | Prostanoid | A | pIC50 | 8.08 | 8.08 | 8.08 | Drug Central |
EP4 | PE2R4 | Rat | Prostanoid | A | pIC50 | 8.06 | 8.06 | 8.06 | Drug Central |
TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 8.0 | 8.0 | 8.0 | ChEMBL |
FP | PF2R | Human | Prostanoid | A | pEC50 | 6.6 | 6.6 | 6.6 | ChEMBL |