PF-05190457


SMILES Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C
InChIKey ZIUDADZJCKGWKR-AREMUKBSSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 512.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7F83

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ghrelin GHSR Mouse Ghrelin A pKi 8.11 8.11 8.11 Guide to Pharmacology
ghrelin GHSR Rat Ghrelin A pKi 8.49 8.49 8.49 Guide to Pharmacology
ghrelin GHSR Human Ghrelin A pKi 8.18 8.18 8.18 ChEMBL
ghrelin GHSR Human Ghrelin A pKi 8.85 8.85 8.85 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.43 5.43 5.43 ChEMBL