ArrestinDb

piclidenoson

Agent/drug
Bioactivity

piclidenoson

SMILES	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O
InChIKey	HUJXGQILHAUCCV-MOROJQBDSA-N

Chemical Properties

Hydrogen bond acceptors	9
Hydrogen bond donors	4
Rotatable bonds	5
Molecular weight (Da)	510.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Structure pdb	8X16
Ligand site mutations	A_2A A₃

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.97	5.97	5.97	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.27	5.27	5.27	ChEMBL
A₁	AA1R	Human	Adenosine	A	pKi	7.29	7.29	7.29	Guide to Pharmacology
A₁	AA1R	Mouse	Adenosine	A	pKi	8.23	8.23	8.23	ChEMBL
A₁	AA1R	Bovine	Adenosine	A	pKi	7.48	7.70	7.92	ChEMBL
A₁	AA1R	Rat	Adenosine	A	pKi	7.27	7.27	7.27	ChEMBL
A₁	AA1R	Human	Adenosine	A	pKi	5.79	7.29	8.43	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pKi	5.60	5.95	6.30	Guide to Pharmacology
A_2A	AA2AR	Mouse	Adenosine	A	pKi	6.00	6.00	6.00	ChEMBL
A_2A	AA2AR	Rat	Adenosine	A	pKi	7.25	7.25	7.25	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pKi	5.21	6.25	7.50	ChEMBL
A_2B	AA2BR	Human	Adenosine	A	pKi	4.30	4.60	4.90	Guide to Pharmacology
A_2B	AA2BR	Human	Adenosine	A	pKi	4.96	5.33	5.69	ChEMBL
A₃	AA3R	Human	Adenosine	A	pKi	8.70	8.95	9.20	Guide to Pharmacology
A₃	AA3R	Mouse	Adenosine	A	pKi	10.06	10.06	10.06	ChEMBL
A₃	AA3R	Rat	Adenosine	A	pKi	7.52	8.85	8.96	ChEMBL
A₃	AA3R	Human	Adenosine	A	pKi	7.96	8.86	10.10	ChEMBL

Showing 1 to 17 of 17 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

A₁	AA1R	Human	Adenosine	A	pEC50	7.50	7.50	7.50	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pEC50	7.10	7.10	7.10	ChEMBL
A_2B	AA2BR	Human	Adenosine	A	pEC50	4.96	6.23	7.50	ChEMBL
A₃	AA3R	Human	Adenosine	A	pEC50	8.44	9.16	9.60	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	7.64	9.57	10.84	ChEMBL
RXFP1	RXFP1	Human	Relaxin family peptide	A	Potency	4.80	4.80	4.80	ChEMBL

Showing 1 to 6 of 6 entries

piclidenoson

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Structure pdb	8X16
Ligand site mutations	A_2A A₃

Compound is not listed as a drug.