ArrestinDb

pimavanserin

Agent/drug
Bioactivity

pimavanserin

SMILES	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1
InChIKey	RKEWSXXUOLRFBX-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	8
Molecular weight (Da)	427.3

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb
Structure pdb	8ZMG
Ligand site mutations	5-HT_2A

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	9.30	9.60	10.20	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.03	8.03	8.03	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	9.30	9.30	9.30	Guide to Pharmacology
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.82	8.82	8.82	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.06	8.06	8.06	Drug Central

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₂	ADRB2	Human	Adrenoceptors	A	pIC50	5.34	5.34	5.34	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.10	7.83	8.73	ChEMBL
apelin	APJ	Human	Apelin	A	pIC50	5.46	5.46	5.46	ChEMBL
CX₃CR1	CX3C1	Human	Chemokine	A	pIC50	5.49	5.49	5.49	ChEMBL
GPR183	GP183	Human	A orphans	A	pIC50	5.36	5.36	5.36	ChEMBL
GPR35	GPR35	Human	A orphans	A	pIC50	5.25	5.25	5.25	ChEMBL
GPR65	PSYR	Human	A orphans	A	pIC50	5.45	5.45	5.45	ChEMBL

Showing 1 to 7 of 7 entries

pimavanserin

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 1

Phase II 1

Phase III 3

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb
Structure pdb	8ZMG
Ligand site mutations	5-HT_2A

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alzheimer disease	8A20	N05A	0.409	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Hallucinations, unspecified	MB27.2Z	N05A	0.472	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified neurocognitive disorders	6E0Y	N05A	0.402	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z	N05A	0.580	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.620	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N05A	0.632	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Tourette syndrome	8A05.00	N05A	0.593	1	Yes

Showing 1 to 7 of 7 entries