ArrestinDb

prazosin

Agent/drug
Bioactivity

prazosin

SMILES	COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC
InChIKey	IENZQIKPVFGBNW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	8
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	383.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb
Ligand site mutations	α_1A α_1B α_2A

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	9.00	9.45	9.90	Guide to Pharmacology
α_1A	ADA1A	Human	Adrenoceptors	A	pKd	9.10	9.10	9.10	Guide to Pharmacology
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	9.50	9.50	9.50	Guide to Pharmacology
α_1A	ADA1A	Rabbit	Adrenoceptors	A	pKd	8.30	8.30	8.30	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	9.03	9.46	9.90	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKd	8.60	9.00	9.81	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.98	9.56	10.15	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.73	9.37	10.40	ChEMBL
α_1A	Q9TSW7	Pig	Adrenoceptors	A	pKi	9.20	9.33	9.60	PDSP Ki database
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.98	7.98	7.98	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.99	7.99	7.99	Drug Central
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	8.01	8.01	8.01	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.70	9.30	9.90	Guide to Pharmacology
α_1B	ADA1B	Human	Adrenoceptors	A	pKd	9.10	9.10	9.10	Guide to Pharmacology
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	9.08	9.08	9.08	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.53	9.59	10.00	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKd	8.99	9.00	9.01	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.10	9.29	9.68	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	9.21	9.72	10.22	PDSP Ki database
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	9.25	9.25	9.25	PDSP Ki database

Showing 1 to 20 of 73 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	9.16	9.47	9.66	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	9.07	9.53	9.75	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	9.06	9.12	9.18	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.58	5.58	5.58	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.54	6.54	6.54	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.19	6.19	6.19	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.38	5.38	5.38	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	8.04	8.04	8.04	Drug Central
D₂	DRD2	Rat	Dopamine	A	pIC50	4.96	4.96	4.96	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	8.30	8.30	8.30	Drug Central
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.55	4.70	4.85	ChEMBL

Showing 1 to 11 of 11 entries

prazosin

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 3

Phase II 15

Phase III 6

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb
Ligand site mutations	α_1A α_1B α_2A

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	C02C, C02L	0.453	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alcohol withdrawal, unspecified	6C40.4Z	C02C, C02L	0.037	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Anxiety	MB24.3	C02C, C02L	0.328	1	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	COVID-19	RA01	C02C, C02L	0.343	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	C02C, C02L	0.444	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neuromuscular dysfunction of bladder, not elsewhere classified	GC01.4	C02C, C02L	0.475	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nicotine dependence, unspecified	6C4A.2Z	C02C, C02L	0.102	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Post traumatic stress disorder	6B40	C02C, C02L	0.548	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Stimulant dependence including amphetamines, methamphetamine or methcathinone, unspecified	6C46.2Z	C02C, C02L	0.074	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	C02C, C02L	0.453	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alcohol withdrawal, unspecified	6C40.4Z	C02C, C02L	0.037	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Anxiety	MB24.3	C02C, C02L	0.328	1	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	COVID-19	RA01	C02C, C02L	0.344	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	C02C, C02L	0.439	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neuromuscular dysfunction of bladder, not elsewhere classified	GC01.4	C02C, C02L	0.342	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nicotine dependence, unspecified	6C4A.2Z	C02C, C02L	0.102	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Post traumatic stress disorder	6B40	C02C, C02L	0.548	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Stimulant dependence including amphetamines, methamphetamine or methcathinone, unspecified	6C46.2Z	C02C, C02L	0.074	2	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	C02C, C02L	0.453	3	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alcohol withdrawal, unspecified	6C40.4Z	C02C, C02L	0.037	2	Yes

Showing 1 to 20 of 27 entries

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prazosin

prazosin

Chemical Properties

Database connections

Bioactivities

prazosin

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information