promazine
| SMILES | CN(CCCN1c2ccccc2Sc2c1cccc2)C |
| InChIKey | ZGUGWUXLJSTTMA-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 3 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 284.1 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 6.52 | 6.52 | 6.52 | Guide to Pharmacology |
| D3 | DRD3 | Human | Dopamine | A | pKi | 6.8 | 6.8 | 6.8 | Guide to Pharmacology |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.34 | 8.34 | 8.34 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 8.43 | 8.43 | 8.43 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.21 | 8.21 | 8.21 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.07 | 8.07 | 8.07 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 7.34 | 7.34 | 7.34 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.43 | 7.43 | 7.43 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pKi | 5.55 | 5.55 | 5.55 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 7.38 | 7.38 | 7.38 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKi | 9.4 | 9.4 | 9.4 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 7.06 | 7.06 | 7.06 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 5.53 | 5.53 | 5.53 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.9 | 6.9 | 6.9 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pKi | 5.91 | 5.91 | 5.91 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 6.9 | 6.9 | 6.9 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 6.66 | 6.66 | 6.66 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 6.41 | 6.41 | 6.41 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.28 | 7.28 | 7.28 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 6.93 | 6.93 | 6.93 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pKi | 7.16 | 7.16 | 7.16 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.17 | 8.17 | 8.17 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pKi | 6.78 | 6.78 | 6.78 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.8 | 7.8 | 7.8 | PDSP Ki database |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 6.89 | 6.89 | 6.89 | PDSP Ki database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 6.52 | 6.7 | 6.8 | PDSP Ki database |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.38 | 8.59 | 8.7 | PDSP Ki database |
| H1 | HRH1 | Rat | Histamine | A | pKi | 7.52 | 7.59 | 7.66 | PDSP Ki database |
| β2 | ADRB2 | Human | Adrenoceptors | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| D1 | DRD1 | Bovine | Dopamine | A | pKi | 5.15 | 5.15 | 5.15 | PDSP Ki database |
| D2 | DRD2 | Bovine | Dopamine | A | pKi | 7.14 | 7.14 | 7.15 | PDSP Ki database |
| D3 | DRD3 | Human | Dopamine | A | pKi | 6.8 | 6.8 | 6.8 | PDSP Ki database |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 8.62 | 8.62 | 8.62 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.26 | 8.26 | 8.26 | Drug Central |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| D1 | DRD1 | Human | Dopamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
| H2 | HRH2 | Human | Histamine | A | pKi | 8.26 | 8.26 | 8.26 | Drug Central |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H1 | HRH1 | Rat | Histamine | A | pIC50 | 5.9 | 5.9 | 5.9 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pIC50 | 8.09 | 8.09 | 8.09 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 8.03 | 8.03 | 8.03 | ChEMBL |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 5.65 | 5.8 | 5.95 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pIC50 | 7.89 | 7.89 | 7.89 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 7.75 | 7.75 | 7.75 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.19 | 7.19 | 7.19 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 6.6 | 6.6 | 6.6 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pIC50 | 5.54 | 5.54 | 5.54 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pIC50 | 6.52 | 6.52 | 6.52 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pIC50 | 5.61 | 7.04 | 8.46 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pIC50 | 6.38 | 6.38 | 6.38 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 5.29 | 5.29 | 5.29 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 6.47 | 6.47 | 6.47 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pIC50 | 5.61 | 5.61 | 5.61 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pIC50 | 6.56 | 6.56 | 6.56 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pIC50 | 6.46 | 6.46 | 6.46 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.96 | 5.96 | 5.96 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pIC50 | 7.0 | 7.0 | 7.0 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 6.31 | 6.31 | 6.31 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pIC50 | 6.69 | 6.69 | 6.69 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pIC50 | 7.64 | 7.64 | 7.64 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pIC50 | 6.3 | 6.3 | 6.3 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 8.28 | 8.28 | 8.28 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 8.1 | 8.1 | 8.1 | Drug Central |
| H1 | HRH1 | Rat | Histamine | A | pIC50 | 8.23 | 8.23 | 8.23 | Drug Central |
| NPS | NPSR1 | Human | Neuropeptide S | A | Potency | 5.0 | 5.0 | 5.0 | ChEMBL |
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 7.4 | 7.4 | 7.4 | ChEMBL |