ArrestinDb

promethazine

Agent/drug
Bioactivity

promethazine

SMILES	CC(CN1c2ccccc2Sc2ccccc21)N(C)C
InChIKey	PWWVAXIEGOYWEE-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	3
Molecular weight (Da)	284.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.50	7.50	7.50	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.68	7.68	7.68	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.05	7.05	7.05	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.59	6.59	6.59	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.62	7.62	7.62	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.45	6.45	6.45	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.83	5.83	5.83	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.72	7.72	7.72	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.37	7.37	7.37	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.13	8.13	8.13	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.09	8.09	8.09	Drug Central

Showing 1 to 20 of 53 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.10	7.10	7.10	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.15	8.15	8.15	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	7.41	7.41	7.41	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	6.74	6.74	6.74	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.17	6.17	6.17	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.28	7.28	7.28	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.61	5.61	5.61	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.59	5.59	5.59	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.25	8.25	8.25	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.17	7.40	7.64	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	7.17	7.17	7.17	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.92	7.92	7.92	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.62	5.62	5.62	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	5.56	5.56	5.56	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.11	6.55	7.00	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	6.25	6.25	6.25	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	8.27	8.40	8.54	ChEMBL
H₂	HRH2	Human	Histamine	A	pIC50	5.93	5.93	5.93	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	7.85	7.85	7.85	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	7.46	7.46	7.46	ChEMBL

Showing 1 to 20 of 23 entries

promethazine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 1

Phase III 3

Phase IV 11

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Allergic conjunctivitis	4	9A60.02	D04A, R06A, V03A	0.589
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Allergic or hypersensitivity conditions of unspecified type	4	4A8Z	D04A, R06A, V03A	0.494
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Allergic rhinitis due to other seasonal allergens	4	CA08.01	D04A, R06A, V03A	0.610
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Atopic eczema, unspecified	4	EA80.Z	D04A, R06A, V03A	0.474
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Crohn disease, unspecified site	2	DD70.Z	D04A, R06A, V03A	0.083
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Migraine with aura, unspecified	3	8A80.1Z	D04A, R06A, V03A	0.323
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Migraine without aura	3	8A80.0	D04A, R06A, V03A	0.323
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Motion sickness	4	NF08.3	D04A, R06A, V03A	0.598
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Nausea	4	MD90.0	D04A, R06A, V03A	0.592
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Nausea or vomiting	4	MD90	D04A, R06A, V03A	0.526
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Other peripheral vertigo	3	AB34.1	D04A, R06A, V03A	0.463
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Pain, unspecified	4	MG3Z	D04A, R06A, V03A	0.591
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Pruritus, unspecified	4	EC90.Z	D04A, R06A, V03A	0.602
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Urticaria of unspecified type	4	EB05	D04A, R06A, V03A	0.606
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Vomiting	4	MD90.1	D04A, R06A, V03A	0.588

Showing 1 to 15 of 15 entries

Join us

Cite us

Main reference

promethazine

promethazine

Chemical Properties

Database connections

Bioactivities

promethazine

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information