Ro4491533


SMILES O=C1CC(=Nc2c(N1)cc(c(c2)C)C(F)(F)F)c1cccc(c1)c1cc(C)nc(c1)C
InChIKey LYTVXCQQTLUEQR-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 423.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 8.27 8.27 8.27 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.44 7.33 8.21 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Rat Metabotropic glutamate C pIC50 6.53 7.62 8.7 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pIC50 6.6 6.6 6.6 Guide to Pharmacology
mGlu3 GRM3 Rat Metabotropic glutamate C pIC50 8.0 8.0 8.0 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pIC50 6.57 6.57 6.57 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pIC50 8.52 8.61 8.7 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 6.53 6.97 7.85 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 7.85 7.85 7.85 Guide to Pharmacology