ArrestinDb

SB 204070

Agent/drug
Bioactivity

SB 204070

SMILES	CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1
InChIKey	AOOSJYIINXVNHV-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	382.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	5.73	5.73	5.73	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.82	5.82	5.82	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.17	6.17	6.17	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.00	6.00	6.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	6.00	6.00	6.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.42	5.42	5.42	ChEMBL
5-HT_1D	5HT1D	Guinea pig	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.02	6.02	6.02	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.28	7.28	7.28	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.20	6.73	7.10	ChEMBL
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	PDSP Ki database
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	9.80	10.11	10.41	Guide to Pharmacology
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	10.80	10.80	10.80	ChEMBL
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pKi	8.90	9.27	9.51	PDSP Ki database
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	10.00	10.00	10.00	PDSP Ki database
5-HT₄	5HT4R	Guinea pig	5-Hydroxytryptamine	A	pKi	10.15	10.57	11.00	PDSP Ki database
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pKi	8.90	9.20	9.50	Guide to Pharmacology

Showing 1 to 20 of 26 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.85	5.05	5.25	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	7.60	7.60	7.60	ChEMBL

Showing 1 to 2 of 2 entries

SB 204070

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.