ArrestinDb

SB-334867

Agent/drug
Bioactivity

SB-334867

SMILES	Cc1nc2ccc(NC(=O)Nc3ccnc4cccnc34)cc2o1
InChIKey	AKMNUCBQGHFICM-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	2
Molecular weight (Da)	319.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	6TQ7

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.40	5.40	5.40	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.92	5.92	5.92	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pKi	6.17	6.17	6.17	ChEMBL
OX₁	OX1R	Human	Orexin	A	pKi	7.20	7.47	7.90	Guide to Pharmacology
OX₁	OX1R	Rat	Orexin	A	pKi	6.84	6.84	6.84	Guide to Pharmacology
OX₁	OX1R	Human	Orexin	A	pKi	7.32	7.65	7.85	ChEMBL
OX₂	OX2R	Human	Orexin	A	pKi	5.20	5.47	6.30	Guide to Pharmacology
OX₂	OX2R	Human	Orexin	A	pKi	5.42	5.87	6.20	ChEMBL

Showing 1 to 8 of 8 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

OX₁	OX1R	Human	Orexin	A	pKB	8.10	8.10	8.10	Guide to Pharmacology
OX₁	OX1R	Human	Orexin	A	pIC50	4.75	6.39	7.40	ChEMBL
OX₂	OX2R	Human	Orexin	A	pKB	6.30	6.30	6.30	Guide to Pharmacology

Showing 1 to 3 of 3 entries

SB-334867

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	6TQ7

Compound is not listed as a drug.