ArrestinDb

SKF-81297

Agent/drug
Bioactivity

SKF-81297

SMILES	Oc1cc2c(c(Cl)c1O)CCNCC2c1ccccc1
InChIKey	GHWJEDJMOVUXEC-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	3
Rotatable bonds	1
Molecular weight (Da)	289.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.26	5.26	5.26	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.82	5.82	5.82	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	8.70	8.70	8.70	Guide to Pharmacology
D₁	DRD1	Human	Dopamine	A	pKi	7.82	7.99	8.15	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	6.95	6.95	6.95	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	8.72	8.72	8.72	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.10	5.80	6.51	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	5.90	5.90	5.90	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	5.00	5.55	6.10	PDSP Ki database

Showing 1 to 10 of 10 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₁	DRD1	Human	Dopamine	A	pEC50	5.02	6.39	8.33	ChEMBL
D₅	DRD5	Human	Dopamine	A	pEC50	8.85	8.85	8.85	ChEMBL
GAL₃	GALR3	Human	Galanin	A	pIC50	5.42	5.42	5.42	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	5.18	5.18	5.18	ChEMBL

Showing 1 to 4 of 4 entries

SKF-81297

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.