tamsulosin


SMILES CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C
InChIKey DRHKJLXJIQTDTD-OAHLLOKOSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 11
Molecular weight (Da) 408.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7YMJ
Ligand site mutations α1A α1B

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Rat Adrenoceptors A pKi 7.1 7.63 8.17 ChEMBL
α1B ADA1B Golden hamster Adrenoceptors A pKi 9.7 9.7 9.7 ChEMBL
α1A ADA1A Rabbit Adrenoceptors A pKd 9.8 9.8 9.8 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKd 9.69 9.69 9.69 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 7.0 8.67 9.21 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 9.89 10.21 10.52 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKd 9.47 9.47 9.47 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 8.4 9.75 10.54 ChEMBL
α1A ADA1A Human Adrenoceptors A pKd 9.54 9.54 9.54 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 8.1 9.65 10.24 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 7.2 7.54 7.87 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 9.7 9.88 10.54 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.04 8.04 8.04 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 9.1 9.1 9.1 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.08 7.08 7.08 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 7.98 7.98 7.98 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 9.7 10.2 10.7 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.7 8.83 9.22 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 8.1 8.9 9.7 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 7.99 7.99 7.99 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 9.2 9.7 10.2 Guide to Pharmacology
α2A ADA2A Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.1 8.1 8.1 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.1 8.1 8.1 Drug Central
D2 DRD2 Human Dopamine A pKi 7.11 7.5 7.89 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.02 8.02 8.02 Drug Central
D3 DRD3 Human Dopamine A pKi 9.55 9.55 9.55 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKi 7.99 7.99 7.99 Drug Central
α1D ADA1D Rat Adrenoceptors A pKi 10.15 10.15 10.15 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKd 10.6 10.6 10.6 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 7.98 7.98 7.98 Drug Central
α2B ADA2B Rat Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
α1B ADA1B Golden hamster Adrenoceptors A pKi 8.01 8.01 8.01 Drug Central
α1A ADA1A Bovine Adrenoceptors A pKi 8.0 8.0 8.0 Drug Central
α1A ADA1A Bovine Adrenoceptors A pKi 9.9 9.9 9.9 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Human Adrenoceptors A pIC50 8.32 8.35 8.38 ChEMBL
α1B ADA1B Human Adrenoceptors A pEC50 9.89 9.89 9.89 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 8.66 9.07 9.49 ChEMBL
α1A ADA1A Human Adrenoceptors A pEC50 10.15 10.15 10.15 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 8.85 9.34 9.82 ChEMBL