ArrestinDb

(+)-sulpiride

Agent/drug
Bioactivity

(+)-sulpiride

SMILES	CCN1CCC[C@@H]1CNC(=O)c1cc(S(N)(=O)=O)ccc1OC
InChIKey	BGRJTUBHPOOWDU-LLVKDONJSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	6
Molecular weight (Da)	341.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central PubChem GPCRdb
Ligand site mutations	D₁ D₂ D₄

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.12	6.12	6.12	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.31	6.23	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.32	5.32	5.32	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	5.30	5.30	5.30	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.30	5.30	5.30	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	5.30	5.41	5.52	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.30	5.30	5.30	PDSP Ki database
D₁	DRD1	Bovine	Dopamine	A	pKi	4.30	4.30	4.30	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Bovine	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Mouse	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Bovine	Dopamine	A	pKi	8.37	8.37	8.37	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	6.28	7.64	8.00	Guide to Pharmacology
D₂	DRD2	Rat	Dopamine	A	pKi	7.00	7.00	7.00	Guide to Pharmacology
D₂	DRD2	Rat	Dopamine	A	pKi	5.57	7.33	8.26	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKd	8.82	8.82	8.82	ChEMBL

Showing 1 to 20 of 40 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.70	5.70	5.70	ChEMBL
D₂	DRD2	Dog	Dopamine	A	pIC50	6.70	6.70	6.70	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	6.63	6.90	7.48	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.69	7.24	7.99	ChEMBL
D₂	DRD2	Dog	Dopamine	A	pIC50	8.17	8.17	8.17	Drug Central
D₃	DRD3	Human	Dopamine	A	pIC50	6.25	6.85	7.18	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.80	4.80	4.80	ChEMBL

Showing 1 to 7 of 7 entries

(+)-sulpiride

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 3

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central PubChem GPCRdb
Ligand site mutations	D₁ D₂ D₄

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anxiety	MB24.3		0.272	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z		0.078	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z		0.404	3	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Gastro-oesophageal reflux disease, unspecified	DA22.Z		0.536	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Irritable bowel syndrome, type unspecified	DD91.0Z		0.538	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z		0.609	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3		0.060	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Vertigo, unspecified	MB48.0Z		0.370	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Anxiety	MB24.3		0.578	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z		0.660	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z		0.655	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Gastro-oesophageal reflux disease, unspecified	DA22.Z		0.558	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Hallucinations, unspecified	MB27.2Z		0.074	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Irritable bowel syndrome, type unspecified	DD91.0Z		0.074	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z		0.732	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3		0.703	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Vertigo, unspecified	MB48.0Z		0.370	4	Yes

Showing 1 to 17 of 17 entries

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(+)-sulpiride

(+)-sulpiride

Chemical Properties

Database connections

Bioactivities

(+)-sulpiride

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information