ArrestinDb

tamsulosin

Agent/drug
Bioactivity

tamsulosin

SMILES	CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(S(N)(=O)=O)c1
InChIKey	DRHKJLXJIQTDTD-OAHLLOKOSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	2
Rotatable bonds	11
Molecular weight (Da)	408.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	7YMJ
Ligand site mutations	α_1A α_1B

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	9.40	10.05	10.70	Guide to Pharmacology
α_1A	ADA1A	Rabbit	Adrenoceptors	A	pKd	9.80	9.80	9.80	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	9.90	9.90	9.90	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKd	9.47	9.47	9.47	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	9.89	10.21	10.52	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKd	9.54	9.54	9.54	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.40	9.75	10.54	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.98	7.98	7.98	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.98	7.98	7.98	Drug Central
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	8.00	8.00	8.00	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.10	8.90	9.70	Guide to Pharmacology
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	9.70	9.70	9.70	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKd	9.69	9.69	9.69	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.00	8.67	9.21	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.70	8.83	9.22	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.04	8.04	8.04	Drug Central
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	8.01	8.01	8.01	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	9.20	9.70	10.20	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.10	9.65	10.24	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	9.70	9.88	10.54	PDSP Ki database

Showing 1 to 20 of 36 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	10.15	10.15	10.15	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	8.66	9.07	9.49	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pIC50	8.32	8.35	8.38	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pEC50	9.89	9.89	9.89	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	8.85	9.34	9.82	ChEMBL

Showing 1 to 5 of 5 entries

tamsulosin

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 5

Phase II 6

Phase III 15

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	7YMJ
Ligand site mutations	α_1A α_1B

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of kidney, unspecified	GB70.0Z	G01A, G04C	0.577	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of ureter	GB70.1	G01A, G04C	0.559	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the urinary system, unspecified	GC2Z	G01A, G04C	0.074	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	G01A, G04C	0.444	1	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hyperplasia of prostate	GA90	G01A, G04C	0.450	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Inflammatory and other diseases of prostate, unspecified	GA91.Z	G01A, G04C	0.290	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Injury or harm arising from surgical or medical care, not elsewhere classified, unspecified	NE8Z	G01A, G04C	0.402	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neuromuscular dysfunction of bladder, not elsewhere classified	GC01.4	G01A, G04C	0.475	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Retention of urine	MF50.3	G01A, G04C	0.531	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of kidney, unspecified	GB70.0Z	G01A, G04C	0.570	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of ureter	GB70.1	G01A, G04C	0.550	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the urinary system, unspecified	GC2Z	G01A, G04C	0.075	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	G01A, G04C	0.439	1	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hyperplasia of prostate	GA90	G01A, G04C	0.447	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Inflammatory and other diseases of prostate, unspecified	GA91.Z	G01A, G04C	0.285	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Injury or harm arising from surgical or medical care, not elsewhere classified, unspecified	NE8Z	G01A, G04C	0.402	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neuromuscular dysfunction of bladder, not elsewhere classified	GC01.4	G01A, G04C	0.342	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Retention of urine	MF50.3	G01A, G04C	0.531	3	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of kidney, unspecified	GB70.0Z	G01A, G04C	0.576	3	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of ureter	GB70.1	G01A, G04C	0.553	3	Yes

Showing 1 to 20 of 27 entries

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tamsulosin

tamsulosin

Chemical Properties

Database connections

Bioactivities

tamsulosin

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information