ArrestinDb

trihexyphenidyl

Agent/drug
Bioactivity

trihexyphenidyl

SMILES	OC(CCN1CCCCC1)(c1ccccc1)C1CCCCC1
InChIKey	HWHLPVGTWGOCJO-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	301.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem GPCRdb
Ligand site mutations	M₁ M₃

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	8.87	8.87	8.87	Guide to Pharmacology
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	8.87	8.87	8.87	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	6.91	8.38	9.43	PDSP Ki database
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	pKi	9.13	9.13	9.13	PDSP Ki database
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	7.92	7.92	7.92	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	6.31	7.54	8.15	PDSP Ki database
M₂	ACM2	Rat	Acetylcholine (muscarinic)	A	pKi	7.86	7.86	7.86	PDSP Ki database
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	8.50	8.50	8.50	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	5.89	7.56	8.61	PDSP Ki database
M₃	ACM3	Rat	Acetylcholine (muscarinic)	A	pKi	8.53	8.53	8.53	PDSP Ki database
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	9.12	9.12	9.12	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	6.57	8.24	9.08	PDSP Ki database
M₄	ACM4	Chicken	Acetylcholine (muscarinic)	A	pKi	8.71	8.71	8.71	PDSP Ki database
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	8.06	8.06	8.06	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	6.17	7.42	8.30	PDSP Ki database

Showing 1 to 15 of 15 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	8.25	8.57	8.89	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	8.05	8.05	8.05	Drug Central
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	7.47	7.60	7.73	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	8.11	8.11	8.11	Drug Central
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	7.58	7.70	7.82	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	8.12	8.12	8.12	Drug Central
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	8.17	8.21	8.26	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	8.09	8.09	8.09	Drug Central
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	7.92	7.96	7.99	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	8.10	8.10	8.10	Drug Central

Showing 1 to 10 of 10 entries

trihexyphenidyl

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 1

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem GPCRdb
Ligand site mutations	M₁ M₃

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ACM1	M₁ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	Class A	Dystonic disorders, unspecified	8A02.Z	N04A	0.074	2	Yes
ACM1	M₁ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z	N04A	0.666	4	Yes

Showing 1 to 2 of 2 entries