ArrestinDb

triprolidine

Agent/drug
Bioactivity

triprolidine

SMILES	Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1
InChIKey	CBEQULMOCCWAQT-WOJGMQOQSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	278.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	H₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₁	HRH1	Human	Histamine	A	pKi	8.50	8.75	9.00	Guide to Pharmacology
H₁	HRH1	Guinea pig	Histamine	A	pKd	9.90	9.90	9.90	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pKi	8.78	8.78	8.78	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	8.80	8.80	8.80	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	5.00	8.39	9.34	PDSP Ki database
H₁	HRH1	Guinea pig	Histamine	A	pKi	8.94	9.15	9.51	PDSP Ki database
H₁	HRH1	Rat	Histamine	A	pKi	8.25	8.25	8.25	PDSP Ki database
H₁	HRH1	Mouse	Histamine	A	pKi	8.04	8.04	8.04	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	8.00	8.00	8.00	Drug Central
H₁	HRH1	Guinea pig	Histamine	A	pKd	8.00	8.00	8.00	Drug Central

Showing 1 to 10 of 10 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

NPS	NPSR1	Human	Neuropeptide S	A	Potency	7.30	7.30	7.30	ChEMBL

Showing 1 to 1 of 1 entry

triprolidine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	H₁

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	R06A	0.605	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z	R06A	0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	R06A	0.610	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z	R06A	0.616	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	R06A	0.607	4	Yes

Showing 1 to 5 of 5 entries