MAZAPERTINE


SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1
InChIKey ZKZFPRUSWCYSGT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 421.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Rat Dopamine A pKi 8.74 8.74 8.74 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.54 5.54 5.54 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 7.33 7.33 7.33 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.54 5.54 5.54 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 7.33 7.33 7.33 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 9.7 9.7 9.7 ChEMBL
D2 DRD2 Rat Dopamine A pKi 8.66 8.66 8.66 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 10.7 10.7 10.7 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.77 8.77 8.77 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.74 8.74 8.74 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.4 8.4 8.4 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.54 5.54 5.54 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 7.33 7.33 7.33 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 10.7 10.7 10.7 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.4 8.4 8.4 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.4 8.4 8.4 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.77 8.77 8.77 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.66 8.66 8.66 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database