(R,R)-TRAMADOL


SMILES COc1cccc([C@@]2(O)CCCC[C@@H]2CN(C)C)c1
InChIKey TVYLLZQTGLZFBW-ZBFHGGJFSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 263.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pKi 5.62 5.62 5.62 ChEMBL
μ OPRM Rat Opioid A pKi 5.67 5.67 5.67 PDSP Ki database
κ OPRK Rat Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
δ OPRD Human Opioid A pKi 8.03 8.03 8.03 PDSP Ki database
κ OPRK Human Opioid A pKi 7.85 7.85 7.85 PDSP Ki database
μ OPRM Human Opioid A pKi 5.8 5.8 5.8 PDSP Ki database
δ OPRD Human Opioid A pKi 8.1 8.1 8.1 Drug Central
κ OPRK Human Opioid A pKi 8.11 8.11 8.11 Drug Central
μ OPRM Human Opioid A pKi 8.24 8.24 8.24 Drug Central
μ OPRM Rat Opioid A pKi 8.25 8.25 8.25 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pIC50 5.28 5.28 5.28 ChEMBL
μ OPRM Human Opioid A pEC50 6.0 6.0 6.0 ChEMBL