ArrestinDb

PALIPERIDONE

Agent/drug
Bioactivity

PALIPERIDONE

SMILES	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O
InChIKey	PMXMIIMHBWHSKN-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	426.2

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	9.15	9.15	9.15	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.04	8.04	8.04	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.60	8.60	8.60	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.52	7.92	8.33	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.24	7.63	8.03	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.96	8.20	8.43	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.15	5.30	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.15	5.30	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
δ	OPRD	Mouse	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database
κ	OPRK	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Guinea pig	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Rat	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.42	6.42	6.42	PDSP Ki database

Showing 1 to 20 of 79 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	8.28	8.28	8.28	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	8.08	8.08	8.08	ChEMBL

Showing 1 to 2 of 2 entries

PALIPERIDONE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 5

Phase III 14

Approved Yes

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Autism spectrum disorder, unspecified	6A02.Z		0.462	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z		0.609	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Obsessive-compulsive disorder, unspecified	6B20.Z		0.561	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z		0.606	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z		0.620	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Autism spectrum disorder, unspecified	6A02.Z		0.527	3	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z		0.605	3	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Obsessive-compulsive disorder, unspecified	6B20.Z		0.539	2	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z		0.604	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z		0.614	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Autism spectrum disorder, unspecified	6A02.Z		0.499	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z		0.660	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Obsessive-compulsive disorder, unspecified	6B20.Z		0.613	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z		0.606	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z		0.732	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Autism spectrum disorder, unspecified	6A02.Z		0.197	3	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z		0.597	3	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Obsessive-compulsive disorder, unspecified	6B20.Z		0.414	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z		0.601	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z		0.704	4	Yes

Showing 1 to 20 of 25 entries

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PALIPERIDONE

PALIPERIDONE

Chemical Properties

Database connections

Bioactivities

PALIPERIDONE

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information