CHEMBL1771110


SMILES COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1
InChIKey AMJCGARHMZJBKQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 8
Molecular weight (Da) 475.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 6.72 6.72 6.72 ChEMBL
D1 DRD1 Pig Dopamine A pKi 6.32 6.32 6.32 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.64 8.64 8.64 ChEMBL
D3 DRD3 Human Dopamine A pKi 9.92 9.92 9.92 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.96 8.06 8.16 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pEC50 8.55 8.55 8.55 ChEMBL