CHEMBL1940404


SMILES OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1
InChIKey JPTSMZMSIACDAD-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 363.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Rat Dopamine A pKi 8.37 8.49 8.62 ChEMBL
D5 DRD5 Human Dopamine A pKi 6.99 6.99 6.99 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.18 6.18 6.18 ChEMBL
H1 HRH1 Human Histamine A pKi 6.16 6.16 6.16 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.66 7.66 7.66 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.79 5.79 5.79 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.74 7.03 7.31 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.03 7.08 7.14 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.5 6.81 7.13 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.06 8.44 8.97 ChEMBL
D2 DRD2 Human Dopamine A pKd 9.1 9.1 9.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database