ArrestinDb

PSILOCYBINE

Agent/drug
Bioactivity

PSILOCYBINE

SMILES	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12
InChIKey	QVDSEJDULKLHCG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	3
Rotatable bonds	5
Molecular weight (Da)	284.1

Database connections

ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
δ	OPRD	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Rat	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.67	5.67	5.67	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.71	6.71	6.71	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.01	7.01	7.01	ChEMBL
5-HT_2B	F6QI78	Bovine	5-Hydroxytryptamine	A	pKi	6.22	6.22	6.22	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.01	7.01	7.01	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.38	6.38	6.38	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	6.22	6.22	6.22	PDSP Ki database
CB₁	CNR1	Human	Cannabinoid	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 20 of 33 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	5.46	5.46	5.46	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pEC50	7.13	7.13	7.13	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pEC50	6.30	6.30	6.30	ChEMBL

Showing 1 to 3 of 3 entries

PSILOCYBINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 6

Phase II 12

Phase III 1

Approved No

Database connections

ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z		0.268	2	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anorexia Nervosa, unspecified	6B80.Z		0.508	2	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anxiety	MB24.3		0.575	1	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z		0.609	2	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Chronic widespread pain	MG30.01		0.561	1	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z		0.460	2	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z		0.607	3	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Disorders due to use of opioids, unspecified	6C43.Z		0.108	2	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Headache, not elsewhere classified	MB4D		0.468	1	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Low back pain, unspecified	ME84.2Z		0.379	2	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Lyme borreliosis, unspecified	1C1G.Z		0.037	1	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z		0.479	1	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Nicotine dependence, unspecified	6C4A.2Z		0.089	2	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Obsessive-compulsive disorder, unspecified	6B20.Z		0.561	1	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified depressive disorders	6A7Y		0.552	2	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Post traumatic stress disorder	6B40		0.585	2	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3		0.632	2	No
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Stimulant dependence including amphetamines, methamphetamine or methcathinone, unspecified	6C46.2Z		0.546	2	No

Showing 1 to 18 of 18 entries

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PSILOCYBINE

PSILOCYBINE

Chemical Properties

Database connections

Bioactivities

PSILOCYBINE

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information