ArrestinDb

brexpiprazole

Agent/drug
Bioactivity

brexpiprazole

SMILES	O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]1
InChIKey	ZKIAIYBUSXZPLP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	433.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.53	7.53	7.53	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.24	7.24	7.24	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.01	8.01	8.01	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.12	7.12	7.12	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.67	6.67	6.67	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.72	6.72	6.72	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.03	8.03	8.03	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.22	7.22	7.22	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.23	6.23	6.23	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	6.01	6.01	6.01	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	10.05	10.05	10.05	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.63	9.16	9.92	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.00	8.00	8.00	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.00	8.00	8.00	Drug Central

Showing 1 to 20 of 51 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Human	Dopamine	A	pEC50	7.79	7.95	8.20	ChEMBL
GPR183	GP183	Human	A orphans	A	pIC50	5.44	5.44	5.44	ChEMBL

Showing 1 to 2 of 2 entries

brexpiprazole

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 11

Phase III 16

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	N05A	0.456	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.591	3	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N05A	0.596	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Personality disorder, severity unspecified	6D10.Z	N05A	0.113	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Post traumatic stress disorder	6B40	N05A	0.554	3	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Restlessness	MB24.F	N05A	0.575	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z	N05A	0.590	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.622	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N05A	0.634	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Sleep-wake disorders, unspecified	7B2Z	N05A	0.261	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	N05A	0.268	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.609	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N05A	0.607	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Personality disorder, severity unspecified	6D10.Z	N05A	0.507	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Post traumatic stress disorder	6B40	N05A	0.585	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Restlessness	MB24.F	N05A	0.602	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z	N05A	0.606	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.620	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N05A	0.632	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Sleep-wake disorders, unspecified	7B2Z	N05A	0.395	3	Yes

Showing 1 to 20 of 44 entries

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brexpiprazole

brexpiprazole

Chemical Properties

Database connections

Bioactivities

brexpiprazole

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information