ARC-239


SMILES COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C
InChIKey OSEADGVOKYGIER-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 406.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKi 5.5 6.15 6.8 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pKi 6.8 7.7 8.6 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 6.7 7.55 8.4 Guide to Pharmacology
α2A ADA2A Human Adrenoceptors A pKi 5.88 6.55 6.88 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.5 7.93 8.42 PDSP Ki database
α2C ADA2C North American opossum Adrenoceptors A pKi 7.32 7.32 7.32 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 7.71 8.14 8.57 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 8.8 8.8 8.8 PDSP Ki database
α2A ADA2A Pig Adrenoceptors A pKi 6.44 6.44 6.44 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database