ArrestinDb

buspirone

Agent/drug
Bioactivity

buspirone

SMILES	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1
InChIKey	QWCRAEMEVRGPNT-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	0
Rotatable bonds	6
Molecular weight (Da)	385.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	8FYX
Ligand site mutations	5-HT_1A D₂

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	5.85	5.85	5.85	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.28	6.28	6.28	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.70	7.85	8.00	Guide to Pharmacology
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	7.34	7.88	8.42	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.30	7.82	8.51	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	8.00	8.00	8.00	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.05	7.67	8.42	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.67	7.56	8.40	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.07	8.07	8.07	Drug Central
5-HT_1A	F6Q2H9	Bovine	5-Hydroxytryptamine	A	pKi	7.70	7.77	7.85	PDSP Ki database
5-HT_1A	A0A4X1UTF5	Pig	5-Hydroxytryptamine	A	pKi	7.58	7.58	7.58	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	7.77	7.77	7.77	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	8.11	8.11	8.11	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.03	PDSP Ki database
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pKi	6.75	6.75	6.75	ChEMBL

Showing 1 to 20 of 53 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Bovine	Adrenoceptors	A	pIC50	4.80	4.80	4.80	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	5.46	5.46	5.46	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pIC50	8.32	8.32	8.32	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.97	5.97	5.97	ChEMBL
α_2A	ADA2A	Bovine	Adrenoceptors	A	pIC50	5.00	5.00	5.00	ChEMBL
α_2A	ADA2A	Bovine	Adrenoceptors	A	pIC50	8.30	8.30	8.30	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	7.22	7.64	8.15	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	7.60	7.60	7.60	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	6.73	7.25	7.82	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	8.14	8.14	8.14	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	4.58	4.74	4.90	ChEMBL
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pIC50	5.00	5.00	5.00	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.64	5.64	5.64	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.12	6.12	6.12	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pIC50	8.22	8.22	8.22	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pIC50	6.00	6.00	6.00	ChEMBL
D₁	DRD1	Bovine	Dopamine	A	pIC50	4.57	4.57	4.57	ChEMBL
D₂	DRD2	Bovine	Dopamine	A	pIC50	5.40	5.40	5.40	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	6.55	6.79	7.26	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.49	6.49	6.49	ChEMBL

Showing 1 to 20 of 22 entries

buspirone

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 4

Phase II 18

Phase III 8

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	8FYX
Ligand site mutations	5-HT_1A D₂

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anxiety	MB24.3	N05B	0.578	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Apnoea	MD11.0	N05B	0.259	3	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z	N05B	0.503	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Autism spectrum disorder, unspecified	6A02.Z	N05B	0.451	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Cannabis dependence, unspecified	6C41.2Z	N05B	0.402	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	N05B	0.107	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N05B	0.596	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Drug-induced dystonia	8A02.10	N05B	0.370	3	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Gastroparesis	DA41.00	N05B	0.074	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Generalised anxiety disorder	6B00	N05B	0.543	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Injury of spinal cord, level unspecified	ND51.2	N05B	0.112	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	N05B	0.306	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified anxiety or fear-related disorders	6B0Y	N05B	0.610	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z	N05B	0.372	1	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z	N05B	0.590	3	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05B	0.622	3	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N05B	0.634	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Systemic sclerosis, unspecified	4A42.Z	N05B	0.022	1	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Anxiety	MB24.3	N05B	0.578	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z	N05B	0.658	2	Yes

Showing 1 to 20 of 34 entries

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buspirone

buspirone

Chemical Properties

Database connections

Bioactivities

buspirone

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information