dynorphin A
SMILES | None |
InChIKey | JMNJYGMAUMANNW-FIXZTSJVSA-N |
Sequence | YGGFLRRIRPKLKWDNQ |
Chemical properties
Hydrogen bond acceptors | None |
Hydrogen bond donors | None |
Rotatable bonds | None |
Molecular weight (Da) |
Drug properties
Molecular type | Peptide |
Physiological/Surrogate | Endogenous |
Approved drug | Yes |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
δ | OPRD | Human | Opioid | A | pKi | 7.4 | 7.4 | 7.4 | Guide to Pharmacology |
κ | OPRK | Human | Opioid | A | pKi | 8.3 | 9.55 | 10.8 | Guide to Pharmacology |
μ | OPRM | Human | Opioid | A | pKi | 8.1 | 8.1 | 8.1 | Guide to Pharmacology |
κ | OPRK | Rat | Opioid | A | pKi | 10.0 | 10.15 | 10.3 | Guide to Pharmacology |
δ | OPRD | Human | Opioid | A | pKi | 8.23 | 8.23 | 8.23 | ChEMBL |
μ | OPRM | Human | Opioid | A | pKi | 8.03 | 8.03 | 8.03 | ChEMBL |
δ | OPRD | Human | Opioid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
κ | OPRK | Human | Opioid | A | pKi | 9.3 | 9.3 | 9.3 | PDSP Ki database |
μ | OPRM | Human | Opioid | A | pKi | 7.49 | 7.49 | 7.49 | PDSP Ki database |
κ | OPRK | Human | Opioid | A | pKi | 9.68 | 9.68 | 9.68 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
κ | OPRK | Mouse | Opioid | A | pIC50 | 9.4 | 9.4 | 9.4 | Guide to Pharmacology |
δ | OPRD | Mouse | Opioid | A | pIC50 | 7.4 | 7.4 | 7.4 | ChEMBL |
κ | OPRK | Guinea pig | Opioid | A | pIC50 | 9.64 | 9.64 | 9.64 | ChEMBL |
δ | OPRD | Human | Opioid | A | pIC50 | 8.6 | 8.6 | 8.6 | ChEMBL |
δ | OPRD | Human | Opioid | A | pEC50 | 7.73 | 7.73 | 7.73 | ChEMBL |
μ | OPRM | Human | Opioid | A | pEC50 | 6.67 | 6.67 | 6.67 | ChEMBL |
κ | OPRK | Human | Opioid | A | pEC50 | 8.2 | 8.82 | 9.39 | ChEMBL |