CHEMBL222477


SMILES O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21
InChIKey OVYNZBZCWFALNG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 439.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 7.29 7.29 7.29 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 7.29 7.29 7.29 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.02 7.02 7.02 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.4 7.4 7.4 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pEC50 4.77 4.77 4.77 ChEMBL